Address Space Layout Randomization(ASLR) and Data Execution Prevention (DEP) and Control Flow Guard (CFG) are default exploit mitigations technique on Windows 10 platform. ASLR and DEP and CFG mitigation significantly increases the difficulty of exploit. In Windows 10, even if you have the ability to arbitrarily address read/write, you still need to find ways to bypass CFG mitigation.
by Henry Li
Full Abstract: https://www.blackhat.com/asia-17/briefings/schedule/index.html#cross-the-wall—bypass-all-modern-mitigations-of-microsoft-edge-5442